The atypical antipsychotics have been associated with metabolic changes, including hyperglycemia, diabetic ketoacidosis, hyperosmolar, hyperglycemic states, and diabetic coma. This study evaluated the longterm effects of alloxan induced diabetes in rat liver. Enhancement of bilirubin excretion in alloxan induced diabetic rats treated with crude aloe vera gel u. Systemic infusion of naloxone reduces degeneration of rat. Diabetes was induced in albino rats by administration of alloxan monohydrate 100mgkg,i. The mechanisms of alloxan and streptozotocininduced diabetes. Alloxaninduced diabetes and bone repair 373 issn 0100879x. Pentazocine hydrochloride pharmacokinetics absorption bioavailability.
Antihyperglycaemic activity of cassia kleinii leaf extract in glucose fed normal rats and alloxaninduced diabetic rats v babu, t gangadevi, a subramoniam. Chloramphenicol, an in vitro inhibitor of the glucuronidation of morphine to its putative antianalgesic metabolite, morphine3glucuronide m3g, was coadministered with morphine in adult male spraguedawley rats to determine whether it inhibited the in vivo metabolism of morphine to m3g, thereby enhancing morphine antinociception andor delaying the development of antinociceptive. The median acute toxicity value ld50 of the drug was determined to be 16. The present study was carried out to investigate the effects of onion allium cepa linn and garlic allium sativum linn juices on biochemical parameters, enzyme activities and lipid peroxidation in alloxaninduced diabetic rats. The rats were randomly divided into 11 groups, and the blood glucose levels of each group are listed in fig. Microangiopathy was confirmed by ophthalmoscopy or by the presence. Twentyfour rats weighing between 55 and 145g were randomly separated into four groups of six rats each and fed water ad libitum. This study evaluated the longterm effects of alloxaninduced diabetes in rat liver. Antihyperglycaemic activity of cassia kleinii leaf. Periodontal disease in diabetic patients presents higher severity and prevalence. Bibliometric statistical properties of the 100 largest european research universities.
The present study was carried out to investigate the effects of onion allium cepa linn and garlic allium sativum linn juices on biochemical parameters, enzyme activities and lipid peroxidation in alloxan induced diabetic rats. However, in absence of aggressive stimuli such as ligatures, the influence of diabetes on. These preliminary biological datadriven readacross studies show the way towards the generation of new readacross approaches that can inform chemical safety assessment. Biochemical study on the hypoglycemic effects of onion and. The animal care committee at the university of brasilia approved all procedures performed. An ideal diabetic chronic wound model, in the macroaspect, should include one or more following criteria. Paraoxonase 1 gene polymorphisms and enzyme activities in.
The effect of desipramine, clonidine, phentolamine, phenoxybenzamine, gd1, normetanephrine and 4. Osim2 1department of physiology, faculty of basic medical sciences, college of health sciences, university of uyo, uyo, akwa ibom state. Diabetes was induced in wistar rats n 25 by intravenous administration of alloxan 42 mgkg and were analyzed at 1, 3, 6, 9 and 12 months after diabetes induction. Faculty collaboration database metronidazoleinduced. Evaluation of antidiabetic activity of ipomoea aquatica. This study describes a rat diabetes mellitus model induced by administering a reduced dose of alloxan, thus greatly reducing the animals death rate. If the inline pdf is not rendering correctly, you can download the pdf file here. Lipid profile of alloxan induced diabetic wistar rats treated with methanolic extract of adansonia digitata fruit pulp demonstratedantidiabetic effect by lowering blood glucose in alloxan induced diabetic rats.
The molecular mechanisms underlying neuropathic pain are constantly being studied to create. Novolin n nph, human insulin isophane rdna origin dose. A massive degeneration of dopaminecontaining neurons in the substantia nigra sn in the midbrain is characteristic of parkinsons disease. Antidiabetic activity of alcoholic stem extract of coscinium fenestratum in streptozotocinnicotinamide induced type 2 diabetic rats. Metronidazoleinduced central nervous system toxicity. The study examined the acute toxicity, hypoglycaemic and hypolipidaemic effects of a polyherbal drug, okudiabet a mixture of stachytarpheta angustifolia, alstonia congensis bark and xylopia aethiopica fruits extract used in the treatment of diabetes. The current study sought to investigate the capacities of single and combinatorial herbal formulations of leaf extracts of acanthus montanus, asystasia gangetica, emilia coccinea, and hibiscus rosasinensis to reverse hyperglycemia and dyslipidemia in alloxaninduced diabetic male rats. Levorphanol was 20 times more potent than dextrorphan in decreasing food. Effect of melatonin supplementation on food and water intake in. Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. Learn about drug interactions between fluconazole oral and indapamide oral and use the rxlist drug interaction checker to check drug combinations. Glucosesensing pulmonary delivery of human coronary artery. Effect of ethanolic extract of pterocarpus marsupium root. Effect of luff aegyptica leaf extract on body weigh in alloxan induced diabetic rats.
Gpr40 is a gprotein coupled receptor regulating free fatty acid induced and also glucose induced insulin secretion. The hemimandibles were removed and submitted to radiographical and histopathological procedures. We generated neonatallystreptozotocintreated female rats nstz and treated them with cnx01167, a gpr40 agonist to examine the role of gpr40 in modulation of glucose metabolism, insulin secretion and content. Electrochemical oxidation of paracetamol mediated by mgb. Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the glut2 glucose transporter. Neurontin and zonisamide drug interactions a study of fda. Streptozotocin use in mice and rats version 1 date of publication. Inflammation in the brain has long been speculated to play a role in the pathogenesis of this neurological disorder. See what the interactions are and for which people. Experimental diabetes induced by alloxan and streptozotocin. Many studies have also demonstrated that ultralow doses of naltrexone inhibit the.
Fresh liver weight and its relationship with body weight were obtained, and liver. To investigate whether insulin reduces the magnitude of oxidative, nitrosative, and. Car is retained in the cytoplasm of noninduced livers and translocates into the nucleus after pb induction mol cell biol 19. Electrochemical oxidation of paracetamol mediated by mgb 2 microparticles modified glassy carbon electrode mohammed zidan, tan wee tee, a. Examples are given for in vitro stem cell models and shortterm in vivo repeated dose studies in rats used to support readacross and category formation. Pentazocine hydrochloride monograph for professionals.
Nitric oxide and inflammatory cytokine productions in. Relief of moderate to severe pain a b c such as that associated with acute and chronic medical disorders including cancer, orthopedic problems, renal or biliary colic, and dental surgery. Rapamycin protects against hepatic injury in streptozotocininduced. Effect of virgin coconut oil supplementation on the. Effects of stzinduced diabetes on the relative weights of kidney, liver and pancreas in albino rats. Novolog insulin aspart rdna origin dose, indications. Fine structural changes in the spinal cord and dorsal root ganglia. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition of gliosis prevents the development of analgesic tolerance to opioids.
Recently, we reported that treatment of primary rat mesencephalic mixed neuronglia cultures with lipopolysaccharide lps led to the. Effect of izol contaminated feed on the heamatological. Female nstz animals were orally administered with cnx. The male rats with average weight 200220 g were divided into four groups n6, control, diabetic induced with a single dose of streptozotocin 50 mgkg body weight, t1 and t2 as treated diabetic with the two fractions of ipomoea aquatica ia61 and ia92, respectively. Ultralow dose naltrexone attenuates chronic morphine. Neurofibrillary tangles in experimental neurolathyrism in. However, no work has been carried out on the effect of such treatment on lipid profile of alloxan induced diabetic rats to the best of our knowledge. Experimental model of induction of diabetes mellitus in rats. This work is a demonstration of an inhalable particle with long residence times in the lungs capable. Experimental models play an important role in understanding such a disease, which is treatable only. Phytochemical composition of the herbal extracts, fasting plasma glucose concentration fpgc, and serum.
Nitric oxide and inflammatory cytokine productions in diabetic rats supplemented with goat milk and soy milk kefir. In the present study, the effects of angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. It is in view of this that this study was designed to investigate the treatment effects ofadansonia digitata extracton the lipid. Original article combined anisodamine and probucol. In the presence of intracellular thiols, especially glutathione, alloxan generates reactive oxygen species ros in a cyclic redox reaction with its reduction product, dialuric acid. Effect of luffa aegyptica leaf extract on blood sugar level in alloxan induced diabetic rats. The present study is designed to evaluate the effect of ethanolic leaf extract of lannea coromandelica houtt merril. Effects of stzinduced diabetes on the relative weights of. Blood glucose level and lipid profile of alloxaninduced. Insulin suppresses endotoxininduced oxidative, nitrosative. Rats were randomly assigned to the diabetic or control group. Apr 16, 2010 the development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Enhancement of bilirubin excretion in alloxan induced. Ultralow dose naltrexone attenuates chronic morphineinduced.
Well absorbed from the gi tract b and from im and subq injection sites. Journal of the american society for information science and technology, vol. The effect of angipars on diabetic neuropathy in stzinduced. Anterior horns of the spinal cord from cervical and lumbar regions and dorsal root ganglia from these same levels were studied for ultrastructural changes in iminodipropionitrile idpn treated rats. The effects of naloxone on human breast cancer progression.
Possible mechanisms include atypical antipsychotic induced insulin resistance or direct betacell inhibition. Effect of pulmonary surfactant and phospholipid hexadecanol. Systemic coadministration of chloramphenicol with intravenous. Neurontin and zonisamide drug interactions a study of fda data summary. Antihyperglycaemic activity of cassia kleinii leaf extract in glucose fed normal rats and alloxan induced diabetic rats v babu, t gangadevi, a subramoniam. The nuclear constitutive active receptor car is a key transcription factor regulating phenobarbital pbinducible transcription of various hepatic genes that encode xenobioticsteroidmetabolizing enzymes. Neurofibrillary tangles in experimental neurolathyrism in rats induced by iminodipropionitrile idpn 1. Fresh liver weight and its relationship with body weight were obtained, and liver tissue was. Diabetes was induced in young, weaned, agematched rat pups by streptozotocin. Possible mechanisms include atypical antipsychoticinduced insulin resistance or direct betacell inhibition.
Drug interactions are reported among people who take neurontin and zonisamide together. Naloxone is very effective, inexpensive, and has been used for this purpose in hospitals and by emergency medical systems since 1970. Tolllike receptor 4 tlr4 activation by bacterial infection, or by sterile inflammatory insult is a primary trigger of spontaneous preterm birth. However, no work has been carried out on the effect of such treatment on lipid profile of alloxan induced diabetic rats to the best. Has been used parenterally for preoperative sedation and analgesia and as an adjunct to surgical anesthesia. The development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Alloxan was administered as a single dose 120 mgkg bw to induce diabetes. The aim of this work was to evaluate the effect of vco on the gut microbiota composition changes in non diabetic and alloxan induced diabetic rats. Tramadol effect on morphine dependency and analgesia in mice. Diabetes was induced in male rats by intraperitoneal. Compromised wound healing in ischemic type 2 diabetic rats. The aim of this study was to assess the behaviour in streptozotocininduced diabetic wistar rats and to evaluate the behavioural effects of caffeine administration.
Histopathological and immunohistochemical study of antidiabetic. Hypoglycemic effect of polyherbal formulation in alloxan. Antihyperglycaemic activity of cassia kleinii leaf extract. Formalin test results indicate that the most number of liking in both 05 and 1540 min is for the mice was pretreated by tramadol 12. Diabetes mellitus was induced by single intraperitoneal injection of 35. Fauna 3 kampus ugm, bulaksumur, yogyakarta 55281, indonesia. Diabetes mellitus is a potentially morbid condition with high prevalence worldwide, thus being a major medical concern. Similarly, saponins from solanum anguivi fruit exhibited hypoglycemic, hypolipidemic, and antioxidant properties in alloxan induced diabetic rats, 82 in which the therapeutic actions of saponins were described in the reports of bhavsar et al. Effects of amlodipine and valsartan on glibenclamidetreated.
Thirty nondiabetic control rats nc and 30 untreated diabetic ud rats were divided into three subgroups sacrificed after 6, 14, or 26 weeks. Rats with stz induced diabetes, with or without afb1 intoxication, had. Effect of a polyherbal formulation, okudiabet, on alloxan. Halim abdullah, zulkarnain zainal and goh joo kheng department of chemistry, universiti putra malaysia 43400 upm serdang, selangor, malaysia school of science, monash university sunway campus. The extent of the reduction in tr ach is dose dependent, with a. Cytoplasmic accumulation of the nuclear receptor car by a. Alloxaninduced diabetes model diabetes was induced by a single intraperitoneal injection of 150 mgkg monohydrated alloxan sigma, st. Aggravation of diabetes mellitus has been reported.
Effects of duration of diabetes on behavioural and cognitive. Induction of diabetic ratsone week after stz injection, all animals with blood glucose above 16. Feb 01, 2000 chloramphenicol, an in vitro inhibitor of the glucuronidation of morphine to its putative antianalgesic metabolite, morphine3glucuronide m3g, was coadministered with morphine in adult male spraguedawley rats to determine whether it inhibited the in vivo metabolism of morphine to m3g, thereby enhancing morphine antinociception andor delaying the development of antinociceptive tolerance. Intravenous injection of alloxan into rabbits, rats, dogs, monkeys, etc. Diabetic rats had significantly impaired behavioural and cognitive functions. Normal salineinjected rats, treated identically, served as controls for this study. Alloxaninduced diabetes and bone repair 373 issn 0100. The effects of levonantradol, a structurally novel cannabinoid. Antidiabetic activity of different extracts of myrtus communis in. Glucosesensing pulmonary delivery of human coronary. This study is created by ehealthme based on reports of 101 people who take neurontin and zonisamide from food and drug. The ethanol extracts of pterocarpus marsupium root at a dose of 200mgkg and 400 mgkg of body weight was administered at single dose per day to diabetes induced rats for a period of 28 days.
122 1561 1359 17 468 1195 812 1058 1216 292 984 449 387 1337 238 323 341 74 1175 479 53 396 269 98 1333 1652 687 239 595 1508 839 1515 1347 315 787 283 1012 1334 802 1455 1303